Mobile Nanobots for Prevention of Root Canal Treatment Failure

Dasgupta, Debayan and Peddi, Shanmukh and Saini, Deepak Kumar and Ghosh, Ambarish (2022) Mobile Nanobots for Prevention of Root Canal Treatment Failure. In: Advanced Healthcare Materials . ISSN 2192-2640

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Abstract

Millions of root canal treatments fail worldwide due to remnant bacteria deep in the dentinal tubules located within the dentine tissue of human teeth. The complex and narrow geometry of the tubules renders current techniques relying on passive diffusion of antibacterial agents ineffective. Here, the potential of actively maneuvered nanobots is investigated to disinfect dentinal tubules, which can be incorporated during a standard root canal procedure. It is demonstrated that magnetically driven nanobots can reach the depths of the tubules not possible with current clinical practices. Subtle alterations of the magnetic drive allow both deep implantations of the nanobots isotopically distributed throughout the dentine and spatially controlled recovery from selected regions, further supported by numerical simulations. Finally, the integration of bactericidal therapeutic modality with the nanobots is demonstrated, thereby validating the tremendous potential of nanobots in dentistry and nanomedicine in general.

Item Type:	Journal Article
Publication:	Advanced Healthcare Materials
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright of this article belongs to the John Wiley and Sons Inc.
Keywords:	active matter; dentine; endodontic reinfection; nanobots; root canal
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering Division of Physical & Mathematical Sciences > Physics
Date Deposited:	23 May 2022 04:30
Last Modified:	23 May 2022 04:30
URI:	https://eprints.iisc.ac.in/id/eprint/72399

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