Thankachan, Jerrin Mathew and Setty, Subba Rao Gangi (2022) KIF13A—A Key Regulator of Recycling Endosome Dynamics. In: Frontiers in Cell and Developmental Biology, 10 . ISSN 2296-634X
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Abstract
Molecular motors of the kinesin superfamily (KIF) are a class of ATP-dependent motor proteins that transport cargo, including vesicles, along the tracks of the microtubule network. Around 45 KIF proteins have been described and are grouped into 14 subfamilies based on the sequence homology and domain organization. These motors facilitate a plethora of cellular functions such as vesicle transport, cell division and reorganization of the microtubule cytoskeleton. Current studies suggest that KIF13A, a kinesin-3 family member, associates with recycling endosomes and regulates their membrane dynamics (length and number). KIF13A has been implicated in several processes in many cell types, including cargo transport, recycling endosomal tubule biogenesis, cell polarity, migration and cytokinesis. Here we describe the recent advances in understanding the regulatory aspects of KIF13A motor in controlling the endosomal dynamics in addition to its structure, mechanism of its association to the membranes, regulators of motor activity, cell type-specific cargo/membrane transport, methods to measure its activity and its association with disease. Thus, this review article will provide our current understanding of the cell biological roles of KIF13A in regulating endosomal membrane remodeling.
| Item Type: | Journal Article |
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| Publication: | Frontiers in Cell and Developmental Biology |
| Additional Information: | The copyright of this article belongs to the authors. |
| Keywords: | BLOC-1; KIF13A; kinesin-3 family; melanosome; Rab22A; recycling endosome |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology |
| Date Deposited: | 25 May 2022 04:30 |
| Last Modified: | 25 May 2022 04:30 |
| URI: | https://eprints.iisc.ac.in/id/eprint/72354 |
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