Scientific validation of toxicological and anti-hyperglycemic effect of Bambusa tulda leaf

Dey, S K and Middha, S K and Usha, T and Foudah, A I and Ekambaram, H and Kamala, A and Samuel, R J and Yusufoglu, H S and Goyal, A K (2021) Scientific validation of toxicological and anti-hyperglycemic effect of Bambusa tulda leaf. In: Indian Journal of Traditional Knowledge, 20 (4). pp. 920-926.

PDF Ind_Jou_Tra_Kno_20-4_920-926_2021 .pdf - Published Version Restricted to Registered users only Download (651kB) | Request a copy

Abstract

Bambusa tulda (Poaceae) is one of the most valuable bamboo species in terms of health-promoting effects. The goal of this research work was to carry out the in-vivo acute toxicity, anti-diabetic and anti-oxidative activities of hydro-methanolic extract of B. tulda leaves. The median lethal dose (LD50) of the hydro-methanolic extract of B. tulda leaves was found to be 6088.13 mg/kg body weight in mice. Supplementing the low (100 mg/kg) and high dose (200 mg/kg) of B. tulda leaf extract showed significant elevation in the endogenous enzymes level of superoxide dismutase (24.81) and glutathione peroxidase (31.60) with a decline in malondialdehyde levels (21.90) when compared to untreated alloxan-induced diabetic control rats. The histopathological assessment of pancreas also showed an increase in β-cells, though not at a significant level. Hence the presence of phyto-constituents substantiates the pharmacological activities of hydro-methanolic extract of B. tulda leaf particularly as a potential candidate for anti-diabetic activity. However, detailed studies are needed to elucidate its exact mechanism of action against diabetes. © 2021, National Institute of Science Communication and Information Resources. All rights reserved.

Item Type:	Journal Article
Publication:	Indian Journal of Traditional Knowledge
Publisher:	National Institute of Science Communication and Information Resources
Additional Information:	The copyright for this article belongs to National Institute of Science Communication and Information Resources
Department/Centre:	Division of Biological Sciences > Central Animal Facility (Formerly Primate Research Laboratory)
Date Deposited:	19 May 2022 10:30
Last Modified:	19 May 2022 10:30
URI:	https://eprints.iisc.ac.in/id/eprint/71882

Actions (login required)

View Item