Marine endophytes from the Indian coasts: The untapped sources of sustainable anticancer drug discovery

Kamat, S and Kumari, M and Sajna, KV and Mohan, Shruthi and Jayabaskaran, C (2022) Marine endophytes from the Indian coasts: The untapped sources of sustainable anticancer drug discovery. In: Sustainable Chemistry and Pharmacy, 27 .

PDF sus_che_pha_27_2022.pdf - Published Version Restricted to Registered users only Download (4MB) | Request a copy

Abstract

For centuries, the Indian outlook on medicines has had foundations in the exploration of her rich biodiversity. Today, natural product (NP) research delivers an ample chemical space for drug discovery for almost every pathological condition. However, endophytes have emerged as a pandora's box of therapeutic secondary metabolites to resolve ecological, sustainability, and cost concerns. Marine sources of endophytes have garnered attention in the pharmaceutical sector, exemplified by increased FDA-approved marine drugs. With chemotherapy being the most common treatment for cancer patients, the need for novel drugs is steeping high. Endophytes from marine sources present a diverse natural productome for anticancer leads, especially for resistant cancers. For the first time, this review highlights the sustainable biotechnological potential of marine endophytes from the 3000 km long Indian coastline, a biogeographic zone. We also discuss the new cell death mechanisms and targets for marine anticancer drugs, emphasizing endophytes isolated from the Indian coasts. The advances in the NP yield enhancement strategies and possible chemical modifications on the product to reduce the complexity and increase the specificity for higher therapeutic value, followed by the challenges and prospects, are also reviewed. © 2022 Elsevier B.V.

Item Type:	Journal Article
Publication:	Sustainable Chemistry and Pharmacy
Publisher:	Elsevier B.V.
Additional Information:	The copyright for this article belongs to Elsevier B.V.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	17 May 2022 06:11
Last Modified:	17 May 2022 06:11
URI:	https://eprints.iisc.ac.in/id/eprint/71746

Actions (login required)

View Item