Tug-of-War between Internal and External Frictions and Viscosity Dependence of Rate in Biological Reactions

Mukherjee, S and Mondal, S and Acharya, S and Bagchi, B (2022) Tug-of-War between Internal and External Frictions and Viscosity Dependence of Rate in Biological Reactions. In: Physical Review Letters, 128 (10).

PDF Phy_rev_128-10_2022.pdf - Published Version Restricted to Registered users only Download (1MB)

Abstract

The role of water in biological processes is studied in three reactions, namely, the Fe-CO bond rupture in myoglobin, GB1 unfolding, and insulin dimer dissociation. We compute both internal and external components of friction on relevant reaction coordinates. In all of the three cases, the cross-correlation between forces from protein and water is found to be large and negative that serves to reduce the total friction significantly, increase the calculated reaction rate, and weaken solvent viscosity dependence. The computed force spectrum reveals bimodal 1/f noise, suggesting the use of a non-Markovian rate theory. © 2022 American Physical Society.

Item Type:	Journal Article
Publication:	Physical Review Letters
Publisher:	American Physical Society
Additional Information:	The copyright for this article belongs to American Physical Society
Keywords:	Binary alloys; Cobalt alloys; Cobalt compounds; Iron alloys; Tugboats; Viscosity, Biological process; Biological reaction; Bond rupture; Cross-correlations; Dimer dissociation; External components; Reaction coordinates; Relevant reactions; Role of water; Unfoldings, Friction
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	16 May 2022 06:38
Last Modified:	16 May 2022 06:38
URI:	https://eprints.iisc.ac.in/id/eprint/71683

Actions (login required)

View Item