Simultaneous Protection and Activation of Amino Acids Using Propargyl Pentafluorophenyl Carbonate

Ramesh, Ramapanicker and Rajasekaran, Sakthidevi and Gupta, Rohit and Chandrasekaran, Srinivasan (2006) Simultaneous Protection and Activation of Amino Acids Using Propargyl Pentafluorophenyl Carbonate. In: Organic Letters, 8 (9). pp. 1933-1936.

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Abstract

A very efficient method for the simultaneous protection of the amino group and activation of the carboxyl group of amino acids is reported using propargyl pentafluorophenyl carbonate (PocOPfp). The amino group is protected as a propargyloxycarbonyl (Poc) derivative, and the carboxyl group is activated as a pentafluorophenyl ester. The yields obtained are good to excellent ranging from 60 to 87%.

Item Type:	Journal Article
Publication:	Organic Letters
Publisher:	American Chemical Society
Additional Information:	Copyright of this article belongs to American Chemical Society.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	31 May 2006
Last Modified:	19 Sep 2010 04:28
URI:	http://eprints.iisc.ac.in/id/eprint/7168

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