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Resolvin D1-loaded nanoliposomes promote M2 macrophage polarization and are effective in the treatment of osteoarthritis

Dravid, AA and M Dhanabalan, K and Agarwal, S and Agarwal, R (2021) Resolvin D1-loaded nanoliposomes promote M2 macrophage polarization and are effective in the treatment of osteoarthritis. In: Bioengineering and Translational Medicine .

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Official URL: https://doi.org/10.1002/btm2.10281


Current treatments for osteoarthritis (OA) offer symptomatic relief but do not prevent or halt the disease progression. Chronic low-grade inflammation is considered a significant driver of OA. Specialized proresolution mediators are powerful agents of resolution but have a short in vivo half-life. In this study, we have engineered a Resolvin D1 (RvD1)-loaded nanoliposomal formulation (Lipo-RvD1) that targets and resolves the OA-associated inflammation. This formulation creates a depot of the RvD1 molecules that allows the controlled release of the molecule for up to 11 days in vitro. In surgically induced mice model of OA, only controlled-release formulation of Lipo-RvD1 was able to treat the progressing cartilage damage when administered a month after the surgery, while the free drug was unable to prevent cartilage damage. We found that Lipo-RvD1 functions by damping the proinflammatory activity of synovial macrophages and recruiting a higher number of M2 macrophages at the site of inflammation. Our Lipo-RvD1 formulation was able to target and suppress the formation of the osteophytes and showed analgesic effect, thus emphasizing its ability to treat clinical symptoms of OA. Such controlled-release formulation of RvD1 could represent a patient-compliant treatment for OA. © 2021 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.

Item Type: Journal Article
Publication: Bioengineering and Translational Medicine
Publisher: John Wiley and Sons Inc
Additional Information: The copyright for this article belongs to John Wiley and Sons Inc
Keywords: Cartilage; Controlled drug delivery; Macrophages; Mammals; Molecules; Pathology; Regenerative Medicine; Targeted drug delivery, Cartilage damage; Controlled release formulations; Current treatments; Disease progression; Inflammatory disease; Nanocarriers; Nanoliposomes; Regenerative medicine; Resolution of inflammation; Specialized proresolution mediator, Diseases
Department/Centre: Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 15 May 2022 08:12
Last Modified: 15 May 2022 08:12
URI: https://eprints.iisc.ac.in/id/eprint/71673

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