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Weighted model-based optoacoustic reconstruction for partial-view geometries

Muhammad, M and Prakash, J and Liapis, E and Ntziachristos, V and Jüstel, D (2022) Weighted model-based optoacoustic reconstruction for partial-view geometries. In: Journal of Biophotonics .

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Official URL: https://doi.org/10.1002/jbio.202100334


Acoustic heterogeneities in biological samples are known to cause artifacts in tomographic optoacoustic (photoacoustic) image reconstruction. A statistical weighted model-based reconstruction approach was previously introduced to mitigate such artifacts. However, this approach does not reliably provide high-quality reconstructions for partial-view imaging systems, which are common in preclinical and clinical optoacoustics. In this article, the capability of the weighted model-based algorithm is extended to generate optoacoustic reconstructions with less distortions for partial-view geometry data. This is achieved by manipulating the weighting scheme based on the detector geometry. Using partial-view optoacoustic tomography data from a tissue-mimicking phantom containing a strong acoustic reflector, tumors grafted onto mice, and a mouse brain with intact skull, the proposed partial-view-corrected weighted model-based algorithm is shown to mitigate reflection artifacts in reconstructed images without distorting structures or boundaries, compared with both conventional model-based and the weighted model-based algorithms. It is also demonstrated that the partial-view-corrected weighted model-based algorithm has the additional advantage of suppressing streaking artifacts due to the partial-view geometry itself in the presence of a very strong optoacoustic chromophore. Due to its enhanced performance, the partial-view-corrected weighted model-based algorithm may prove useful for improving the quality of partial-view multispectral optoacoustic tomography, leading to enhanced visualization of functional parameters such as tissue oxygenation. © 2022 The Authors. Journal of Biophotonics published by Wiley-VCH GmbH.

Item Type: Journal Article
Publication: Journal of Biophotonics
Publisher: John Wiley and Sons Inc
Additional Information: The copyright for this article belongs to the authors
Keywords: Chromophores; Image reconstruction; Photoacoustic effect; Repair; Tissue; Tomography, Acoustic heterogeneity; Model based reconstruction; Model-based algorithms; Optoacoustic (photoacoustic) imaging; Partial views; Partial-view correction; Photo-acoustic imaging; Streaking artifact; Weighted model-based reconstruction; Weighted models, Geometry
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 12 May 2022 11:25
Last Modified: 12 May 2022 11:25
URI: https://eprints.iisc.ac.in/id/eprint/71657

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