Mulimani, MK and Zimik, S and Pandit, R (2022) An In Silico Study of Electrophysiological Parameters That Affect the Spiral-Wave Frequency in Mathematical Models for Cardiac Tissue. In: Frontiers in Physics, 9 .
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Abstract
Spiral waves of excitation in cardiac tissue are associated with life-threatening cardiac arrhythmias. It is, therefore, important to study the electrophysiological factors that affect the dynamics of these spiral waves. By using an electrophysiologically detailed mathematical model of a myocyte (cardiac cell), we study the effects of cellular parameters, such as membrane-ion-channel conductances, on the properties of the action-potential (AP) of a myocyte. We then investigate how changes in these properties, specifically the upstroke velocity and the AP duration (APD), affect the frequency � of a spiral wave in the mathematical model that we use for human-ventricular tissue. We find that an increase (decrease) in this upstroke-velocity or a decrease (increase) in the AP duration increases (decreases) �. We also study how other intercellular factors, such as the fibroblast-myocyte coupling, diffusive coupling strength, and the effective number of neighboring myocytes and fibroblasts, modulate �. Finally, we demonstrate how a spiral wave can drift to a region with a high density of fibroblasts. Our results provide a natural explanation for the anchoring of spiral waves in highly fibrotic regions in fibrotic hearts. Copyright © 2022 Mulimani, Zimik and Pandit.
| Item Type: | Journal Article |
|---|---|
| Publication: | Frontiers in Physics |
| Publisher: | Frontiers Media S.A. |
| Additional Information: | The copyright for this article belongs to Authors |
| Department/Centre: | Division of Physical & Mathematical Sciences > Physics |
| Date Deposited: | 16 Mar 2022 06:10 |
| Last Modified: | 16 Mar 2022 06:10 |
| URI: | http://eprints.iisc.ac.in/id/eprint/71495 |
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