A Study of Properties of the 2 2+-Dependent Delayed Afterdepolarizations in a Mathematical Model for Human Ventricular Myocytes

Roshan, N and Pandit, R (2021) A Study of Properties of the 2 2+-Dependent Delayed Afterdepolarizations in a Mathematical Model for Human Ventricular Myocytes. In: 2021 Computing in Cardiology, CinC 2021, 13-15 Sep 2021, Brno.

PDF com_car_2021.pdf - Published Version Restricted to Registered users only Download (1MB) | Request a copy

Abstract

Delayed afterdepolarizations (DADs), observed in cardiac myocytes can be arrhythmogenic. These DADs may arise in diseased conditions or mutations that induce numerous changes in the expression levels of exchangers, ion channels, or ionic pumps. It is difficult to reproduce these changes in experiments; therefore, we carry out a detailed in silico study of these modifications in the human ventricular myocyte model due to ten Tusscher and Panfilov (TP06). We find three types of DADs. Furthermore, by using parameter-sensitivity analysis, we show that the mathrmNmathrma + - mathrmCmathrma2 + exchanger and the SERCA pump uptake rate are the critical parameters for triggering DADs. We also show that the mathrmNmathrma + - mathrmCmathrma2 + conductance increases the DAD amplitude, whereas the SERCA uptake rate increases the frequency of the DADs. We obtain a phase diagram for the TP06 model and present regions of parameter space which show various types of DADs. © 2021 Creative Commons.

Item Type:	Conference Paper
Publication:	Computing in Cardiology
Publisher:	IEEE Computer Society
Additional Information:	The copyright for this article belongs to IEEE Computer Society
Keywords:	Sensitivity analysis, Afterdepolarization; Cardiac myocytes; Condition; Expression levels; In-silico; Ion channel; Ionic pump; Property; Uptake rate; Ventricular myocytes, Cardiology
Department/Centre:	Division of Physical & Mathematical Sciences > Physics
Date Deposited:	09 Mar 2022 10:25
Last Modified:	09 Mar 2022 10:25
URI:	http://eprints.iisc.ac.in/id/eprint/71472

Actions (login required)

View Item