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Sterile inflammation alters neutrophil kinetics in mice

Alakesh, A and Jothiprakasam, T and Raghavan, JV and Jhunjhunwala, S (2022) Sterile inflammation alters neutrophil kinetics in mice. In: Journal of Leukocyte Biology .

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Official URL: https://doi.org/10.1002/JLB.1A0321-132RR


Neutrophils play a crucial role in establishing inflammation in response to an infection or injury, but their production rates, as well as blood and tissue residence times, remain poorly characterized under these conditions. Herein, using a biomaterial implant model to establish inflammation followed by in vivo tracking of newly formed neutrophils, we determine neutrophil kinetics under inflammatory conditions. To obtain quantifiable information from our experimental observations, we develop an ordinary differential equation-based mathematical model to extract kinetic parameters. Our data show that in the presence of inflammation resulting in emergency granulopoiesis-like conditions, neutrophil maturation time in the bone marrow reduces by around 60 and reduced half-life in the blood, compared with noninflammatory conditions. Additionally, neutrophil residence time at the inflammatory site increases by 2-fold. Together, these data improve our understanding of neutrophil kinetics under inflammatory conditions, which could pave the way for therapies that focus on modulating in vivo neutrophil dynamics. ©2022 Society for Leukocyte Biology

Item Type: Journal Article
Publication: Journal of Leukocyte Biology
Publisher: John Wiley and Sons Inc
Additional Information: The copyright for this article belongs to Authors
Department/Centre: Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 16 Mar 2022 06:07
Last Modified: 16 Mar 2022 06:07
URI: http://eprints.iisc.ac.in/id/eprint/71452

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