Alakesh, A and Jothiprakasam, T and Raghavan, JV and Jhunjhunwala, S (2022) Sterile inflammation alters neutrophil kinetics in mice. In: Journal of Leukocyte Biology .
Full text not available from this repository.Abstract
Neutrophils play a crucial role in establishing inflammation in response to an infection or injury, but their production rates, as well as blood and tissue residence times, remain poorly characterized under these conditions. Herein, using a biomaterial implant model to establish inflammation followed by in vivo tracking of newly formed neutrophils, we determine neutrophil kinetics under inflammatory conditions. To obtain quantifiable information from our experimental observations, we develop an ordinary differential equation-based mathematical model to extract kinetic parameters. Our data show that in the presence of inflammation resulting in emergency granulopoiesis-like conditions, neutrophil maturation time in the bone marrow reduces by around 60 and reduced half-life in the blood, compared with noninflammatory conditions. Additionally, neutrophil residence time at the inflammatory site increases by 2-fold. Together, these data improve our understanding of neutrophil kinetics under inflammatory conditions, which could pave the way for therapies that focus on modulating in vivo neutrophil dynamics. ©2022 Society for Leukocyte Biology
| Item Type: | Journal Article |
|---|---|
| Publication: | Journal of Leukocyte Biology |
| Publisher: | John Wiley and Sons Inc |
| Additional Information: | The copyright for this article belongs to Authors |
| Department/Centre: | Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering |
| Date Deposited: | 16 Mar 2022 06:07 |
| Last Modified: | 16 Mar 2022 06:07 |
| URI: | http://eprints.iisc.ac.in/id/eprint/71452 |
Actions (login required)
 |
View Item |
