Kumar, S and Rangarajan, A and Pal, D (2022) Somatic mutation analyses of stem-like cells in gingivobuccal oral squamous cell carcinoma reveals DNA damage response genes. In: Genomics, 114 (2).
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Abstract
Gingivobuccal oral squamous cell carcinoma (OSCC-GB) occurs among persons who excessively chew smokeless tobacco in India. To understand the role of cancer stem cells (CSCs) in the disease, we have performed transcriptomics analysis on RNA-seq data from OSCC-GB primary tumors. The mutational signature analysis of the identified novel and Catalogue of Somatic Mutations in Cancer (COSMIC) variants reveals DNA damage associated etiology based on identified COSMIC signatures showing a higher prevalence of C > T mutations and 1 bp T/(A) nucleotide insertions, pointing to the role of smokeless tobacco carcinogens. The differential somatic mutational, functional impact predictions, and survival analysis reveals the role of DNA damage response-related genes, with the CREBBP gene as a major player. The new CSC somatic variants identified in the study may play a crucial role in cancer metastasis, local-regional recurrence, chemo- and/or radioresistance that contributes to high mortality of the Indian OSCC-GB patients. © 2021
| Item Type: | Journal Article |
|---|---|
| Publication: | Genomics |
| Publisher: | Academic Press Inc. |
| Additional Information: | The copyright for this article belongs to Authors |
| Department/Centre: | Division of Biological Sciences > Molecular Reproduction, Development & Genetics Division of Interdisciplinary Sciences > Computational and Data Sciences Division of Physical & Mathematical Sciences > Mathematics |
| Date Deposited: | 16 Mar 2022 06:06 |
| Last Modified: | 16 Mar 2022 06:06 |
| URI: | http://eprints.iisc.ac.in/id/eprint/71434 |
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