Bimodal Turn-On Fluorescent Probe for Photophysical and Electrochemical Detection of Human Serum Albumin in Clinical Samples

Saha, P and Moitra, P and Bhattacharjee, U and Bhattacharya, S (2022) Bimodal Turn-On Fluorescent Probe for Photophysical and Electrochemical Detection of Human Serum Albumin in Clinical Samples. In: Advanced Materials Interfaces .

PDF adv_mat_int_2022.pdf - Published Version Restricted to Registered users only Download (1MB) | Request a copy

Abstract

A simple, easy to synthesize, cost-effective fluorescent turn-on sensor is developed for the selective detection of human serum albumin (HSA) in both biological and environmental samples. The biosensor is unique with qualities of rapidly quantifying HSA levels both at lower and higher concentrations in divergent bio-fluids with high sensitivity. This probe has also been successfully used for the quantitative determination of serum albumin levels in a large number of patients� samples having different clinical manifestations. Electrochemical detection of HSA concentrations can also be achieved with this biosensor using a potentiostat. Thus, this probe offers a unique potential of diagnosing HSA levels directly from patient samples using its bimodal (i.e., photophysical and electrochemical) properties, which are hitherto unknown to date. © 2022 Wiley-VCH GmbH

Item Type:	Journal Article
Publication:	Advanced Materials Interfaces
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to John Wiley and Sons Inc
Keywords:	Biosensors; Chemical detection; Cost effectiveness; Diagnosis; Fluorescence; Voltage regulators, Biological samples; Clinical samples; Cost effective; ELectrochemical detection; Fluorescent probes; Human serum albumins; Photophysical; Selective detection; Simple++; Turn-on sensors, Probes
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	14 Feb 2022 15:39
Last Modified:	14 Feb 2022 15:39
URI:	http://eprints.iisc.ac.in/id/eprint/71352

Actions (login required)

View Item