Iyer, S and Yadav, R and Agarwal, S and Tripathi, S and Agarwal, R (2022) Bioengineering Strategies for Developing Vaccines against Respiratory Viral Diseases. In: Clinical microbiology reviews, 35 (1). e0012321.
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Abstract
Respiratory viral pathogens like influenza and coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have caused outbreaks leading to millions of deaths. Vaccinations are, to date, the best and most economical way to control such outbreaks and have been highly successful for several pathogens. Currently used vaccines for respiratory viral pathogens are primarily live attenuated or inactivated and can risk reversion to virulence or confer inadequate immunity. The recent trend of using potent biomolecules like DNA, RNA, and protein antigenic components to synthesize vaccines for diseases has shown promising results. Still, it remains challenging to translate due to their high susceptibility to degradation during storage and after delivery. Advances in bioengineering technology for vaccine design have made it possible to control the physicochemical properties of the vaccines for rapid synthesis, heightened antigen presentation, safer formulations, and more robust immunogenicity. Bioengineering techniques and materials have been used to synthesize several potent vaccines, approved or in trials, against coronavirus disease 2019 (COVID-19) and are being explored for influenza, SARS, and Middle East respiratory syndrome (MERS) vaccines as well. Here, we review bioengineering strategies such as the use of polymeric particles, liposomes, and virus-like particles in vaccine development against influenza and coronaviruses and the feasibility of adopting these technologies for clinical use.
| Item Type: | Journal Article |
|---|---|
| Publication: | Clinical microbiology reviews |
| Publisher: | NLM (Medline) |
| Additional Information: | The copyright for this article belongs to NLM (Medline) |
| Keywords: | bioengineering; human; vaccination, Bioengineering; COVID-19; Humans; SARS-CoV-2; Vaccination; Vaccine Development |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering |
| Date Deposited: | 14 Feb 2022 15:37 |
| Last Modified: | 14 Feb 2022 15:37 |
| URI: | http://eprints.iisc.ac.in/id/eprint/71329 |
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