Raman spectroscopic study of cinnamyl-1 diphenylmethyl-4 piperazine (Cinnarizine) at high pressure

Trivedi, JU and Ghalsasi, P and Ganguly, S and Jenepha Mary, SJ and James, C (2022) Raman spectroscopic study of cinnamyl-1 diphenylmethyl-4 piperazine (Cinnarizine) at high pressure. In: Journal of Molecular Structure, 1253 .

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Abstract

Raman spectra of Cinnarizine in the 35�3400 cm-1 region were studied at high pressures up to 15.3 GPa, using a Diamond Anvil Cell. Broadening of bands is observed starting from �0.9 up to �11�12 GPa pressures as evidenced by the changes in the Raman spectra of some modes. Plots of frequency vs pressure of bands, show increase of frequency with pressure for most of the bands and the slopes, d�/dP, of some bands show clear changes around �2.7, �5, �7.5 �9 and �11�12 GPa indicating phase transformation caused by changes in structure and chemical bonds at these pressures. The present article describes high pressure effects on cinnarizine studied by Raman Spectroscopy and is supported by density function theoretical calculations. © 2021 Elsevier B.V.

Item Type:	Journal Article
Publication:	Journal of Molecular Structure
Publisher:	Elsevier B.V.
Additional Information:	The copyright for this article belongs to Elsevier B.V.
Keywords:	Biochemistry; Bond strength (chemical); Density functional theory; High pressure effects; High pressure engineering; Raman scattering; Spectroscopic analysis, Biochemical systems; Cinnarizine; Diamond anvil cell; Diamond-anvil cell; High pressure; High-pressure effects; Phases transformation; Raman spectroscopic study; Theoretical calculations, Raman spectroscopy
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	07 Jan 2022 06:08
Last Modified:	07 Jan 2022 06:08
URI:	http://eprints.iisc.ac.in/id/eprint/70907

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