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Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs

Bhat, US and Shahi, N and Surendran, S and Babu, K (2021) Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs. In: Frontiers in Molecular Neuroscience, 14 .

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Official URL: https://doi.org/10.3389/fnmol.2021.786471


One of the reasons that most multicellular animals survive and thrive is because of the adaptable and plastic nature of their nervous systems. For an organism to survive, it is essential for the animal to respond and adapt to environmental changes. This is achieved by sensing external cues and translating them into behaviors through changes in synaptic activity. The nervous system plays a crucial role in constantly evaluating environmental cues and allowing for behavioral plasticity in the organism. Multiple neurotransmitters and neuropeptides have been implicated as key players for integrating sensory information to produce the desired output. Because of its simple nervous system and well-established neuronal connectome, C. elegans acts as an excellent model to understand the mechanisms underlying behavioral plasticity. Here, we critically review how neuropeptides modulate a wide range of behaviors by allowing for changes in neuronal and synaptic signaling. This review will have a specific focus on feeding, mating, sleep, addiction, learning and locomotory behaviors in C. elegans. With a view to understand evolutionary relationships, we explore the functions and associated pathophysiology of C. elegans neuropeptides that are conserved across different phyla. Further, we discuss the mechanisms of neuropeptidergic signaling and how these signals are regulated in different behaviors. Finally, we attempt to provide insight into developing potential therapeutics for neuropeptide-related disorders. Copyright © 2021 Bhat, Shahi, Surendran and Babu.

Item Type: Journal Article
Publication: Frontiers in Molecular Neuroscience
Publisher: Frontiers Media S.A.
Additional Information: The copyright for this article belongs to the Author.
Department/Centre: Division of Biological Sciences > Centre for Neuroscience
Date Deposited: 05 Jan 2022 11:16
Last Modified: 05 Jan 2022 11:16
URI: http://eprints.iisc.ac.in/id/eprint/70891

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