Evaluation of antimycobacterial, antioxidant, and anticancer activities of CuO nanoparticles through cobalt doping

Sathyananda, HM and Prashanth, PA and Prashanth, GK and Dileep, MS and Boselin Prabhu, SR and Nagabhushana, BM and Shivakumara, C and Nagendra, HG (2022) Evaluation of antimycobacterial, antioxidant, and anticancer activities of CuO nanoparticles through cobalt doping. In: Applied Nanoscience (Switzerland), 12 (1). pp. 79-86.

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Abstract

Here, we report the synthesis of cobalt-doped copper oxide nanoparticles (CuO–NPs) via combustion strategy with lime juice as a reductant at relatively low temperature of 600 °C and at shorter duration of 3 h. Powder X-ray diffraction (XRD) results revealed that, every compound was in monoclinic structure with space group C12/C1 (No. 15) and average particle size were found to be 18–21 nm. These NPs were used to evaluate the antimycobacterial activity against “Mycobacterium tuberculosis H37Rv ATCC 27294”, “Mycobacterium abscessus ATCC 19977”, “Mycobacterium fortuitum ATCC 6841”, “Mycobacterium chelonae ATCC 35752” and anticancer activity on MDA-MB-231. Antioxidant activity was evaluated by DPPH method. The results showed that, doping CuO with cobalt improved the antimycobacterial, anticancer and scavenging activities of CuO–NPs.

Item Type:	Journal Article
Publication:	Applied Nanoscience (Switzerland)
Publisher:	Springer Science and Business Media Deutschland GmbH
Additional Information:	The copyright for this article belongs to the publisher Springer Science and Business Media Deutschland GmbH.
Keywords:	Anticarcinogenic; Antimycobacterial; Antioxidant; Cobalt doping; CuO–NPs
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	31 Dec 2021 07:15
Last Modified:	08 Jul 2022 05:23
URI:	https://eprints.iisc.ac.in/id/eprint/70873

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