Amino Acid-Functionalized MoS2Quantum Dots for Selective Antibacterial Activity

Mondal, A and De, M (2021) Amino Acid-Functionalized MoS2Quantum Dots for Selective Antibacterial Activity. In: ACS Applied Nano Materials .

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Abstract

The surface functionalization of nanomaterial is relevant in terms of its selectivity toward a bacterial strain. Recently, semiconducting nanomaterials have been gaining much attention in the development of nanomaterial-based alternative antibiotics. Among the various semiconducting materials, molybdenum disulfide (MoS2) has been gaining considerable interest due to its unique electronic, physical, and chemical properties. The semiconducting nature, high colloidal stability, and biocompatibility make it a promising candidate in the field of biomedical research. The development of antibacterial material based on MoS2 quantum dots is still in its infancy. Here, we have explored the effect of hydrophobic amino acid-modified MoS2 quantum dots toward their antibacterial activity. Functionalization enhances the antibacterial activity and selectivity depending on the amino acid residue. MoS2 quantum dots with a leucine-functionalized ligand show selective antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), whereas MoS2 quantum dots with a phenylalanine-functionalized ligand show almost equal antibacterial efficacy against both MRSA and Pseudomonas aeruginosa (PA). © 2021 American Chemical Society.

Item Type:	Journal Article
Publication:	ACS Applied Nano Materials
Publisher:	American Chemical Society
Additional Information:	The copyright for this article belongs to American Chemical Society
Keywords:	Amino acids; Bacteria; Biocompatibility; Layered semiconductors; Ligands; Molybdenum compounds; Nanocrystals; Nanostructured materials; Sulfur compounds, 2d-MoS2; Amino-acids; Anti-bacterial activity; Bacterial strains; Functionalized; Functionalized ligands; Methicillin-resistant staphylococcus aureus; Nanoantibiotic; ROS; Surface Functionalization, Semiconductor quantum dots
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	04 Jan 2022 05:41
Last Modified:	04 Jan 2022 05:41
URI:	http://eprints.iisc.ac.in/id/eprint/70859

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