Distal CA1 maintains a more coherent spatial representation than proximal CA1 when local and global cues conflict

Deshmukh, SS (2021) Distal CA1 maintains a more coherent spatial representation than proximal CA1 when local and global cues conflict. In: Journal of Neuroscience, 41 (47). pp. 9767-9781.

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Abstract

Entorhinal cortical projections show segregation along the transverse axis of CA1, with the medial entorhinal cortex (MEC) sending denser projections to proximal CA1 (pCA1) and the lateral entorhinal cortex (LEC) sending denser projections to distal CA1 (dCA1). Previous studies have reported functional segregation along the transverse axis of CA1 correlated with the functional differences in MEC and LEC. pCA1 shows higher spatial selectivity than dCA1 in these studies. We employ a double rotation protocol, which creates an explicit conflict between the local and the global cues, to understand the differential contributions of these reference frames to the spatial code in pCA1 and dCA1 in male Long-Evans rats. We show that pCA1 and dCA1 respond differently to this local-global cue conflict. pCA1 representation splits as predicted from the strong conflicting inputs it receives from MEC and dCA3. In contrast, dCA1 rotates more in concert with the global cues. In addition, pCA1 and dCA1 display comparable levels of spatial selectivity in this study. This finding differs from the previous studies, perhaps because of richer sensory information available in our behavior arena. Together, these observations indicate that the functional segregation along proximodistal axis of CA1 is not of the amount of spatial selectivity but that of the nature of the different inputs used to create and anchor spatial representations. Copyright © 2021 the authors

Item Type:	Journal Article
Publication:	Journal of Neuroscience
Publisher:	Society for Neuroscience
Additional Information:	The copyright for this article belongs to Society for Neuroscience.
Department/Centre:	Division of Biological Sciences > Centre for Neuroscience
Date Deposited:	06 Jan 2022 06:17
Last Modified:	06 Jan 2022 06:17
URI:	http://eprints.iisc.ac.in/id/eprint/70828

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