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Gold nanoparticles: Phospholipid membrane interactions

Santhosh, PB (2021) Gold nanoparticles: Phospholipid membrane interactions. In: Advances in Biomembranes and Lipid Self-Assembly .

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Official URL: https://doi.org/10.1016/bs.abl.2021.11.006


In the recent decades, there has been a tremendous increase in the use of nanoparticles in various biomedical applications including imaging, drug delivery and therapy. Among the different types of particles, gold nanoparticles are extensively used in nanomedicine due to their unique properties such as surface plasmon resonance, ease of synthesis and ability to conjugate with a wide variety of molecules such as antibodies, peptides and drugs. As the exposure of nanoparticles increases, there are general concerns about their toxicity, bio-distribution and excretion. Various factors such as formation of protein corona and physiochemical properties of the nanoparticles such as their size, shape and surface chemistry are well-known to affect the nanoparticle-membrane interactions. Fundamental understanding of the nano-biointeractions is critical to assure their safety and improve their efficacy. This chapter provides an overview of how the gold nanoparticles with different physiochemical properties interact with the phospholipid membranes, their consequent effects on membrane properties such as fluidity and bending elasticity, cellular uptake and cytotoxicity. Recent findings on the influence of protein corona and interactions of gold nanoparticles with the real cell and model phospholipid membranes via molecular dynamics studies is also discussed to provide a better understanding, which is critical to design smart nanoparticles with improved multifunctional features for advanced biological applications. © 2021 Elsevier Inc.

Item Type: Journal Article
Publication: Advances in Biomembranes and Lipid Self-Assembly
Publisher: Elsevier B.V.
Additional Information: The copyright for this article belongs to Elsevier B.V.
Department/Centre: Division of Interdisciplinary Sciences > Centre for Nano Science and Engineering
Date Deposited: 13 Dec 2021 11:33
Last Modified: 13 Dec 2021 11:33
URI: http://eprints.iisc.ac.in/id/eprint/70742

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