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Epidermal Lamellar Body Biogenesis: Insight Into the Roles of Golgi and Lysosomes

Mahanty, S and Setty, SRG (2021) Epidermal Lamellar Body Biogenesis: Insight Into the Roles of Golgi and Lysosomes. In: Frontiers in Cell and Developmental Biology, 9 .

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Official URL: https://doi.org/10.3389/fcell.2021.701950


Epidermal lamellar bodies (eLBs) are secretory organelles that carry a wide variety of secretory cargo required for skin homeostasis. eLBs belong to the class of lysosome-related organelles (LROs), which are cell-type-specific organelles that perform diverse functions. The formation of eLBs is thought to be related to that of other LROs, which are formed either through the gradual maturation of Golgi/endosomal precursors or by the conversion of conventional lysosomes. Current evidence suggests that eLB biogenesis presumably initiate from trans-Golgi network and receive cargo from endosomes, and also acquire lysosome characteristics during maturation. These multistep biogenesis processes are frequently disrupted in human skin disorders. However, many gaps remain in our understanding of eLB biogenesis and their relationship to skin diseases. Here, we describe our current understanding on eLB biogenesis with a focus on cargo transport to this LRO and highlight key areas where future research is needed. Copyright © 2021 Mahanty and Setty.

Item Type: Journal Article
Publication: Frontiers in Cell and Developmental Biology
Publisher: Frontiers Media S.A.
Additional Information: The copyright for this article belongs to Authors
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 22 Nov 2021 09:48
Last Modified: 22 Nov 2021 09:48
URI: http://eprints.iisc.ac.in/id/eprint/70566

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