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On the origin of better hemocompatibility of the BCxNyOz coatings

Bhaskar, N and Sulyaeva, V and Gatapova, E and Kaichev, V and Khomyakov, M and Kolodin, A and Kosinova, M and Basu, B (2022) On the origin of better hemocompatibility of the BCxNyOz coatings. In: Applied Surface Science, 576 .

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Official URL: https://doi.org/10.1016/j.apsusc.2021.151760


The development of hemocompatible coatings on metallic implants is one of the challenges for blood-contacting implantable devices. In this paper, we investigated the blood-material interaction of BCxNyOz coatings deposited on Ti-6Al-4V substrates, using reactive radiofrequency magnetron sputtering technique with variation in nitrogen (N2) flow rate. A series of experiments, including hemolysis tests, erythrocytes, and platelets adhesion and activation analysis, dynamic blood coagulation, and plasma recalcification time tests, were performed to understand the blood-material interactions, qualitatively and quantitatively. The results revealed that the degree of hemolysis on all the samples was below 2.5, suggesting their favourable interaction with RBCs. The interactions between erythrocytes and platelets with all the BCxNyOz coatings were reduced significantly compared to Ti-6Al-4V. BCxNyOz coatings could substantially delay the time of blood coagulation to the period of 60 min. The plasma recalcification time of coatings was also increased significantly. An effort has been made to rationalize the difference in hardness or blood compatibility parameters in terms of N/B or N/C ratio. The present study conclusively establishes that BCxNyOz coatings can significantly enhance hemocompatibility, thereby opening up a myriad of biomedical applications. © 2021

Item Type: Journal Article
Publication: Applied Surface Science
Publisher: Elsevier B.V.
Additional Information: The copyright for this article belongs to Elsevier B.V.
Keywords: Activation analysis; Chemical activation; Coagulation; Coatings; Medical applications; Metal implants; Platelets; Ternary alloys; Titanium alloys, BCxNyOz; Bioactive coatings; Blood coagulation; Blood-material interactions; Haemocompatibility; Implantable devices; Metallic implants; Plasma recalcification time; Reactive radio-frequency magnetron sputtering; Ti-6al-4v, Aluminum alloys
Department/Centre: Division of Chemical Sciences > Materials Research Centre
Date Deposited: 18 Nov 2021 11:08
Last Modified: 18 Nov 2021 11:08
URI: http://eprints.iisc.ac.in/id/eprint/70524

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