ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

Extrusion-based 3D printing of gelatin methacryloyl with nanocrystalline hydroxyapatite

Das, S and Basu, B (2022) Extrusion-based 3D printing of gelatin methacryloyl with nanocrystalline hydroxyapatite. In: International Journal of Applied Ceramic Technology, 19 (2). pp. 924-938.

[img] PDF
int_jou_app_cer_tec_19-2_924-938_2022.pdf - Published Version
Restricted to Registered users only

Download (4MB) | Request a copy
Official URL: https://doi.org/10.1111/ijac.13885


The particle shape and size distribution of inorganic fillers play a crucial role in the scaffold buildability when those are incorporated in the viscoelastic polymers. In order to address this issue, the phase pure rod-shaped nanocrystalline hydroxyapatite (HAp) powders with varying particle sizes and shapes were synthesized by a one-pot hydrothermal method without any regulatory surfactant at an initial solution pH of 9. As-synthesized nanocrystalline HAp particles (0–5 wt%) were incorporated into 15 wt% pre-cross-linked gelatin methacryloyl (GelMA) hydrogel matrix to fabricate a predesigned scaffold architecture using a custom-made 3D bioprinter. The printing parameters (nozzle diameter, extrusion pressure, and printing speed) were optimized for each composition. The biophysical properties (uniaxial compression behavior, swelling ratio, and in vitro degradation) of the composite hydrogel scaffolds were critically analyzed to unravel the role of nano-sized HAp addition. The compression strength and modulus were substantially improved, while the rate of water uptake and bio-enzymatic degradation significantly reduced with HAp content. We propose that the inorganic–organic nanocomposite hydrogel could be efficiently assembled to formulate a potential bioink for 3D bioprinting applications toward tissue regeneration.

Item Type: Journal Article
Publication: International Journal of Applied Ceramic Technology
Publisher: John Wiley and Sons Inc
Additional Information: The copyright for this article belongs to the John Wiley and Sons Inc.
Keywords: 3D printers; Biodegradation; Cellulose; Extrusion; Hydrogels; Nanocomposites; Nanocrystals; Polymer matrix composites; Scaffolds (biology); Tissue regeneration, 3-D printing; 3D-printing; Ceramic hydrogel matrix; Extrusion printing; Hydrogel matrix; Nanocrystallines; Particle shape and size; Shape distribution; Size-distribution; Synthesised, Hydroxyapatite
Department/Centre: Division of Chemical Sciences > Materials Research Centre
Date Deposited: 28 Nov 2021 09:41
Last Modified: 30 Jun 2022 05:15
URI: https://eprints.iisc.ac.in/id/eprint/70356

Actions (login required)

View Item View Item