Emerging roles of Sirtuin 2 in cardiovascular diseases

Taneja, A and Ravi, V and Hong, JY and Lin, H and Sundaresan, NR (2021) Emerging roles of Sirtuin 2 in cardiovascular diseases. In: FASEB Journal, 35 (10).

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Abstract

Sirtuins are a family of NAD+-dependent deacetylases implicated in a wide variety of age-associated pathologies, including cardiovascular disorders. Among the seven mammalian sirtuins, SIRT2 modulates various cellular processes through the deacetylation or deacylation of their target proteins. Notably, the levels of SIRT2 in the heart decline with age and other pathological conditions, leading to cardiovascular dysfunction. In the present review, we discuss the emerging roles of SIRT2 in cardiovascular dysfunction and heart failure associated with factors like age, hypertension, oxidative stress, and diabetes. We also discuss the potential of using inhibitors to study the unexplored role of SIRT2 in the heart. While SIRT2 undoubtedly plays a crucial role in the cardiovascular system, its functions are only beginning to be understood, making it an attractive candidate for further research in the field. © 2021 Federation of American Societies for Experimental Biology

Item Type:	Journal Article
Publication:	FASEB Journal
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to John Wiley and Sons Inc
Department/Centre:	Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited:	29 Nov 2021 11:09
Last Modified:	29 Nov 2021 11:09
URI:	http://eprints.iisc.ac.in/id/eprint/70274

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