Precision of Protein Thermometry

Vennettilli, M and Saha, S and Roy, U and Mugler, A (2021) Precision of Protein Thermometry. In: Physical Review Letters, 127 (9).

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Abstract

Temperature sensing is a ubiquitous cell behavior, but the fundamental limits to the precision of temperature sensing are poorly understood. Unlike in chemical concentration sensing, the precision of temperature sensing is not limited by extrinsic fluctuations in the temperature field itself. Instead, we find that precision is limited by the intrinsic copy number, turnover, and binding kinetics of temperature-sensitive proteins. Developing a model based on the canonical TlpA protein, we find that a cell can estimate temperature to within 2. We compare this prediction with in vivo data on temperature sensing in bacteria. © 2021 American Physical Society.

Item Type:	Journal Article
Publication:	Physical Review Letters
Publisher:	American Physical Society
Additional Information:	The copyright for this article belongs to American Physical Society
Keywords:	Proteins, Binding kinetics; Cell behaviors; Chemical concentrations; Copy number; In-vivo; Model-based OPC; Temperature sensing; Temperature sensitive, Temperature sensors
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	03 Dec 2021 07:16
Last Modified:	03 Dec 2021 07:16
URI:	http://eprints.iisc.ac.in/id/eprint/70148

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