Visvanathan, A and Somasundaram, K (2017) Glioma Stem-Like Cells in Tumor Growth and Therapy Resistance of Glioblastoma. [Book Chapter]
Full text not available from this repository.Abstract
Glioblastoma is detrimental brain tumor with less than 2 years of life expectancy. They are refractory to conventional therapy and show high relapse rate. GBM tumors exhibit diverse intra-tumoral heterogeneity with multidirectional evolution of clones created by plethora of genetic and epigenetic events. Plasticity being an obstacle in targeting the GBM cells, discovery of glioma stem like cells (GSCs) a decade ago shed light on the dark side of GBM. The intrinsic escape pathways and quiescence encoded within GSCs in combination with niche signals offer advantages like resistance to radio/chemotherapy, high invasion and migration capabilities, trans-differentiation and enhanced self-renewal to tumor. This chapter summarizes the recent advances in the field of GSCs including the distinct molecular characteristics and importance of GSCs in therapy resistance. Though enormous attempts to deduce the puzzle of GSCs were made, the perspective in conjunction with whole tumor studies is still at stake which emphasize the requirement of in-depth studies. © 2017, Springer International Publishing AG.
| Item Type: | Book Chapter |
|---|---|
| Publication: | Current Cancer Research |
| Series.: | Current Cancer Research |
| Publisher: | Springer Nature |
| Additional Information: | The copyright for this article belongs to Springer Nature |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology |
| Date Deposited: | 01 Dec 2021 14:42 |
| Last Modified: | 01 Dec 2021 14:42 |
| URI: | http://eprints.iisc.ac.in/id/eprint/70040 |
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