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Paper-microfluidic signal-enhanced immunoassays

Sathishkumar, N and Toley, BJ (2021) Paper-microfluidic signal-enhanced immunoassays. [Book Chapter]

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Official URL: https://doi.org/10.1016/bs.pmbts.2021.07.015


Over the past decade, paper-based microfluidic devices have become popular for their simplicity and ability to conduct diagnostic tests at a low cost. An important class of diagnostic assays that paper-based analytical devices have been used for is immunoassays. The lateral flow immunoassay (LFIA), of which the home pregnancy test is the most prominent example, has been one of the most commercially successful membrane-based diagnostic tests. Yet, the analytical sensitivity of LFIAs is lower than the corresponding laboratory technique called ELISA (enzyme-linked immunoassay). As a consequence, traditional LFIAs fail to deliver on the promise of bedside diagnostic testing for many applications. Recognizing this shortcoming, several new developments have been made by researchers to enhance the sensitivity of membrane-based immunoassays. In this chapter, we present the various strategies that have been employed to this end. In the end, we present a brief SWOT analysis to guide future work in this area. © 2021 Elsevier Inc.

Item Type: Book Chapter
Publication: Progress in Molecular Biology and Translational Science
Series.: Progress in Molecular Biology and Translational Science
Publisher: Elsevier B.V.
Additional Information: The copyright for this article belongs to Elsevier B.V
Department/Centre: Division of Mechanical Sciences > Chemical Engineering
Date Deposited: 28 Nov 2021 09:30
Last Modified: 28 Nov 2021 09:30
URI: http://eprints.iisc.ac.in/id/eprint/69966

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