Rhodium(iii)-catalyzed 5+1 annulation of 2-alkenylphenols with maleimides: Access to highly functionalized spirocyclic skeletons

Kumar, A and Prabhu, KR (2021) Rhodium(iii)-catalyzed 5+1 annulation of 2-alkenylphenols with maleimides: Access to highly functionalized spirocyclic skeletons. In: Chemical Communications, 57 (66). pp. 8194-8197.

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Abstract

A new edition of 5+1 annulation reaction of maleimides with 2-alkenylphenols has been discovered under a Rh(iii)-catalytic system. The process leads to an efficient synthesis of valued spirocyclic scaffolds bearing an oxygen-containing spiro carbon in a single step and shows a broad substrate scope with good functional group tolerance. The synthetic utility has been exemplified by synthesizing highly functionalized 2,2-disubstituted-2H-chromene skeletons and a gram-scale synthesis with a low catalyst loading. © The Royal Society of Chemistry.

Item Type:	Journal Article
Publication:	Chemical Communications
Publisher:	Royal Society of Chemistry
Additional Information:	The copyright for this article belongs to Royal Society of Chemistry
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	25 Sep 2021 12:39
Last Modified:	25 Sep 2021 12:39
URI:	http://eprints.iisc.ac.in/id/eprint/69793

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