Understanding the DNA double-strand break repair and its therapeutic implications

Ray, U and Raghavan, SC (2021) Understanding the DNA double-strand break repair and its therapeutic implications. In: DNA Repair, 106 .

PDF dna_rep_106_2021.pdf - Published Version Restricted to Registered users only Download (3MB) | Request a copy

Abstract

Repair of DNA double-strand breaks (DSBs) and its regulation are tightly integrated inside cells. Homologous recombination, nonhomologous end joining and microhomology mediated end joining are three major DSB repair pathways in mammalian cells. Targeting proteins associated with these repair pathways using small molecule inhibitors can prove effective in tumors, especially those with deregulated repair. Sensitization of cancer to current age therapy including radio and chemotherapy, using small molecule inhibitors is promising and warrant further development. Although several are under clinical trial, till date no repair inhibitor is approved for commercial use in cancer patients, with the exception of PARP inhibitors targeting single-strand break repair. Based on molecular profiling of repair proteins, better prognostic and therapeutic output can be achieved in patients. In the present review, we highlight the different mechanisms of DSB repair, chromatin dynamics to provide repair accessibility and modulation of inhibitors in association with molecular profiling and current gold standard treatment modalities for cancer. © 2021 Elsevier B.V.

Item Type:	Journal Article
Publication:	DNA Repair
Publisher:	Elsevier B.V.
Additional Information:	The copyright for this article belongs to Elsevier B.V.
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	21 Sep 2021 09:31
Last Modified:	21 Sep 2021 09:31
URI:	http://eprints.iisc.ac.in/id/eprint/69762

Actions (login required)

View Item