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Spatial waves and temporal oscillations in vertebrate limb development

Newman, SA and Bhat, R and Glimm, T (2021) Spatial waves and temporal oscillations in vertebrate limb development. In: BioSystems, 208 .


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Official URL: https://doi.org/10.1016/j.biosystems.2021.104502


The mesenchymal tissue of the developing vertebrate limb bud is an excitable medium that sustains both spatial and temporal periodic phenomena. The first of these is the outcome of general Turing-type reaction-diffusion dynamics that generate spatial standing waves of cell condensations. These condensations are transformed into the nodules and rods of the cartilaginous, and eventually (in most species) the bony, endoskeleton. In the second, temporal periodicity results from intracellular regulatory dynamics that generate oscillations in the expression of one or more gene whose products modulate the spatial patterning system. Here we review experimental evidence from the chicken embryo, interpreted by a set of mathematical and computational models, that the spatial wave-forming system is based on two glycan-binding proteins, galectin-1A and galectin-8 in interaction with each other and the cells that produce them, and that the temporal oscillation occurs in the expression of the transcriptional coregulator Hes1. The multicellular synchronization of the Hes1 oscillation across the limb bud serves to coordinate the biochemical states of the mesenchymal cells globally, thereby refining and sharpening the spatial pattern. Significantly, the wave-forming reaction-diffusion-based mechanism itself, unlike most Turing-type systems, does not contain an oscillatory core, and may have evolved to this condition as it came to incorporate the cell-matrix adhesion module that enabled its pattern-forming capability. © 2021 The Authors

Item Type: Journal Article
Publication: BioSystems
Publisher: Elsevier Ireland Ltd
Additional Information: The copyright for this article belongs to Authors
Keywords: adhesion; biochemistry; bud; cell component; detection method; embryo; gene expression; macroinvertebrate; matrix; oscillation; periodicity; vertebrate, Gallus gallus; Vertebrata
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Date Deposited: 24 Sep 2021 07:58
Last Modified: 24 Sep 2021 07:58
URI: http://eprints.iisc.ac.in/id/eprint/69750

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