Micro-structural investigations on oppositely charged mixed surfactant gels with potential dermal applications

Barai, M and Manna, E and Sultana, H and Mandal, MK and Guchhait, KC and Manna, T and Patra, A and Chang, C-H and Moitra, P and Ghosh, C and Larsson, A-C and Bhattacharya, S and Panda, AK (2021) Micro-structural investigations on oppositely charged mixed surfactant gels with potential dermal applications. In: Scientific Reports, 11 (1).

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Abstract

Dicarboxylic amino acid-based surfactants (N-dodecyl derivatives of -aminomalonate, -aspartate, and -glutamate) in combination with hexadecyltrimethylammonium bromide (HTAB) form a variety of aggregates. Composition and concentration-dependent mixtures exhibit liquid crystal, gel, precipitate, and clear isotropic phases. Liquid crystalline patterns, formed by surfactant mixtures, were identified by polarizing optical microscopy. FE-SEM studies reveal the existence of surface morphologies of different mixed aggregates. Phase transition and associated weight loss were found to depend on the composition where thermotropic behaviours were revealed through combined differential scanning calorimetry and thermogravimetric studies. Systems comprising more than 60 mol HTAB demonstrate shear-thinning behaviour. Gels cause insignificant toxicity to human peripheral lymphocytes and irritation to bare mouse skin; they do not display the symptoms of cutaneous irritation, neutrophilic invasion, and inflammation (erythema, edema, and skin thinning) as evidenced by cumulative irritancy index score. Gels also exhibit substantial antibacterial effects on Staphylococcus aureus, a potent causative agent of skin and soft tissue infections, suggesting its possible application as a vehicle for topical dermatological drug delivery. © 2021, The Author(s).

Item Type:	Journal Article
Publication:	Scientific Reports
Publisher:	Nature Research
Additional Information:	The copyright for this article belongs to Authors
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	22 Sep 2021 09:59
Last Modified:	22 Sep 2021 09:59
URI:	http://eprints.iisc.ac.in/id/eprint/69726

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