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The basal ganglia control the detailed kinematics of learned motor skills

Dhawale, AK and Wolff, SBE and Ko, R and �lveczky, BP (2021) The basal ganglia control the detailed kinematics of learned motor skills. In: Nature Neuroscience, 24 . pp. 1256-1269.

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Official URL: https://doi.org/10.1038/s41593-021-00889-3


The basal ganglia are known to influence action selection and modulation of movement vigor, but whether and how they contribute to specifying the kinematics of learned motor skills is not understood. Here, we probe this question by recording and manipulating basal ganglia activity in rats trained to generate complex task-specific movement patterns with rich kinematic structure. We find that the sensorimotor arm of the basal ganglia circuit is crucial for generating the detailed movement patterns underlying the acquired motor skills. Furthermore, the neural representations in the striatum, and the control function they subserve, do not depend on inputs from the motor cortex. Taken together, these results extend our understanding of the basal ganglia by showing that they can specify and control the fine-grained details of learned motor skills through their interactions with lower-level motor circuits. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.

Item Type: Journal Article
Publication: Nature Neuroscience
Publisher: Nature Research
Additional Information: The copyright for this article belongs to Nature Research
Department/Centre: Division of Biological Sciences > Centre for Neuroscience
Date Deposited: 02 Sep 2021 08:42
Last Modified: 02 Sep 2021 08:42
URI: http://eprints.iisc.ac.in/id/eprint/69681

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