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Urinary bladder and urethral tissue engineering, and 3D bioprinting approaches for urological reconstruction

Chowdhury, SR and Keshavan, N and Basu, B (2021) Urinary bladder and urethral tissue engineering, and 3D bioprinting approaches for urological reconstruction. In: Journal of Materials Research .

Full text not available from this repository.
Official URL: https://doi.org/10.1557/s43578-021-00255-w


Abstract: In the last few decades, tissue engineering evolved as an exciting multidisciplinary field of research. The primary objective of this review is to critically analyze 3D bioprinting-based tissue engineering approaches for urinary bladder and urethra reconstruction. This review critically examines the in vitro and in vivo outcomes of natural, artificial, and hybrid scaffolds. The translational strategies at achieving clinically desired properties and an overview of biomechanical characteristics of urological biomaterials are discussed here. Notably, since the bladder is under continuous dynamic loading and unloading conditions, it is highlighted that 3D bioprinted scaffolds should withstand the biomechanical forces experienced by the native urological tissues and mimic the viscoelastic property of the native bladder tissue. It has been emphasized that 3D bioprinting with biomolecular hydrogel-functional bioink may be a possible solution to create tissue-engineered patient-specific grafts. The review closes with the authors� perspective on relevant challenges associated with the clinical translation. Graphic abstract: Figure not available: see fulltext.. © 2021, The Author(s), under exclusive licence to The Materials Research Society.

Item Type: Journal Article
Publication: Journal of Materials Research
Publisher: Springer Nature
Additional Information: The copyright for this article belongs to Springer Nature
Keywords: 3D printers; Biomechanics; Dynamic loads; Image reconstruction; Scaffolds (biology); Unloading, Biomechanical characteristics; Clinical translation; Continuous dynamics; Hybrid scaffolds; Patient specific; Primary objective; Urinary bladder; Viscoelastic properties, Tissue
Department/Centre: Division of Chemical Sciences > Materials Research Centre
Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 25 Aug 2021 11:46
Last Modified: 25 Aug 2021 11:46
URI: http://eprints.iisc.ac.in/id/eprint/69365

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