ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

Inflammasome regulation in driving COVID-19 severity in humans and immune tolerance in bats

Nagaraja, S and Jain, D and Kesavardhana, S (2021) Inflammasome regulation in driving COVID-19 severity in humans and immune tolerance in bats. In: Journal of Leukocyte Biology .

jou_leu_bio_2021.pdf - Published Version

Download (2MB) | Preview
Image (TIFF)
jlb10936-sup-0001-figures1.tif - Published Supplemental Material

Download (4MB) | Preview
Official URL: https://doi.org/10.1002/JLB.4COVHR0221-093RR


Coronaviruses (CoVs) are RNA viruses that cause human respiratory infections. Zoonotic transmission of the SARS-CoV-2 virus caused the recent COVID-19 pandemic, which led to over 2 million deaths worldwide. Elevated inflammatory responses and cytotoxicity in the lungs are associated with COVID-19 severity in SARS-CoV-2-infected individuals. Bats, which host pathogenic CoVs, operate dampened inflammatory responses and show tolerance to these viruses with mild clinical symptoms. Delineating the mechanisms governing these host-specific inflammatory responses is essential to understand host�virus interactions determining the outcome of pathogenic CoV infections. Here, we describe the essential role of inflammasome activation in determining COVID-19 severity in humans and innate immune tolerance in bats that host several pathogenic CoVs. We further discuss mechanisms leading to inflammasome activation in human SARS-CoV-2 infection and how bats are molecularly adapted to suppress these inflammasome responses. We also report an analysis of functionally important residues of inflammasome components that provide new clues of bat strategies to suppress inflammasome signaling and innate immune responses. As spillover of bat viruses may cause the emergence of new human disease outbreaks, the inflammasome regulation in bats and humans likely provides specific strategies to combat the pathogenic CoV infections. ©2021 Society for Leukocyte Biology

Item Type: Journal Article
Publication: Journal of Leukocyte Biology
Publisher: John Wiley and Sons Inc
Additional Information: The copyright for this article belongs to Authors
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 18 Aug 2021 10:36
Last Modified: 18 Aug 2021 10:36
URI: http://eprints.iisc.ac.in/id/eprint/69267

Actions (login required)

View Item View Item