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Towards decoding the coupled decision-making of metabolism and epithelial-to-mesenchymal transition in cancer

Jia, D and Park, JH and Kaur, H and Jung, KH and Yang, S and Tripathi, S and Galbraith, M and Deng, Y and Jolly, MK and Kaipparettu, BA and Onuchic, JN and Levine, H (2021) Towards decoding the coupled decision-making of metabolism and epithelial-to-mesenchymal transition in cancer. In: British Journal of Cancer .

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Official URL: https://doi.org/10.1038/s41416-021-01385-y


Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis. A developmental programme known as epithelial-to-mesenchymal transition (EMT) plays a critical role during metastasis, promoting the loss of polarity and cell�cell adhesion and the acquisition of motile, stem-cell characteristics. Cells undergoing EMT or the reverse mesenchymal-to-epithelial transition (MET) are often associated with metabolic changes, as the change in phenotype often correlates with a different balance of proliferation versus energy-intensive migration. Extensive crosstalk occurs between metabolism and EMT, but how this crosstalk leads to coordinated physiological changes is still uncertain. The elusive connection between metabolism and EMT compromises the efficacy of metabolic therapies targeting metastasis. In this review, we aim to clarify the causation between metabolism and EMT on the basis of experimental studies, and propose integrated theoretical�experimental efforts to better understand the coupled decision-making of metabolism and EMT. © 2021, The Author(s), under exclusive licence to Cancer Research UK.

Item Type: Journal Article
Publication: British Journal of Cancer
Publisher: Springer Nature
Additional Information: The copyright for this article belongs to Authors
Department/Centre: Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 06 Aug 2021 10:02
Last Modified: 06 Aug 2021 10:02
URI: http://eprints.iisc.ac.in/id/eprint/69150

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