Khand, BK and Bhonde, RR (2021) Can functionally mature islet β-cells be derived from pluripotent stem cells? A step towards ready-to-use β-cells in type 1 diabetes. In: Current Stem Cell Research and Therapy, 16 (3). pp. 231-237.
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Pluripotent Stem Cells PSCs are emerging as an excellent cellular source for the treatment of many degenerative diseases such as diabetes, ischemic heart failure, Alzheimer�s disease, etc. PSCderived pancreatic islet β-cells appear to be a promising therapy for type 1 diabetic patients with impaired β-cell function. Several protocols have been developed to derive β-cells from PSCs. However, these protocols produce β-like cells that show low glucose stimulated insulin secretion (GSIS) function and mirror GSIS profile of functionally immature neonatal β-cells. Several studies have documented a positive correlation between the sirtuins (a family of ageing-related proteins) and the GSIS function of adult β-cells. We are of the view that the GSIS function of PSC-derived β-like cells could be enhanced by improving the function of sirtuins in them. Studying the sirtuin expression and activation pattern during the β-cell development and inclusion of the sirtuin activators and inhibitor cocktail (specific to a developmental stage) in the present protocols may help us derive functionally mature, ready-to-use βcells in-vitro making them suitable for transplantation in type 1 diabetes. © 2021 Bentham Science Publishers.
| Item Type: | Journal Article |
|---|---|
| Publication: | Current Stem Cell Research and Therapy |
| Publisher: | Bentham Science Publishers |
| Additional Information: | The copyright for this article belongs to Bentham Science Publishers |
| Department/Centre: | Division of Biological Sciences > Molecular Reproduction, Development & Genetics |
| Date Deposited: | 10 Aug 2021 06:38 |
| Last Modified: | 10 Aug 2021 06:38 |
| URI: | http://eprints.iisc.ac.in/id/eprint/69138 |
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