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Intermediate adhesion maximizes migration velocity of multicellular clusters

Roy, U and Mugler, A (2021) Intermediate adhesion maximizes migration velocity of multicellular clusters. In: Physical Review E, 103 (3).

phy_rev_103-03_2021.pdf - Published Version

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Official URL: https://doi.org/10.1103/PhysRevE.103.032410


Collections of cells exhibit coherent migration during morphogenesis, cancer metastasis, and wound healing. In many cases, bigger clusters split, smaller subclusters collide and reassemble, and gaps continually emerge. The connections between cell-level adhesion and cluster-level dynamics, as well as the resulting consequences for cluster properties such as migration velocity, remain poorly understood. Here we investigate collective migration of one- and two-dimensional cell clusters that collectively track chemical gradients using a mechanism based on contact inhibition of locomotion. We develop both a minimal description based on the lattice gas model of statistical physics and a more realistic framework based on the cellular Potts model which captures cell shape changes and cluster rearrangement. In both cases, we find that cells have an optimal adhesion strength that maximizes cluster migration speed. The optimum negotiates a tradeoff between maintaining cell-cell contact and maintaining configurational freedom, and we identify maximal variability in the cluster aspect ratio as a revealing signature. Our results suggest a collective benefit for intermediate cell-cell adhesion. © 2021 American Physical Society.

Item Type: Journal Article
Publication: Physical Review E
Publisher: American Physical Society
Additional Information: The copyright for this article belongs to Authors
Keywords: Aspect ratio; Cell adhesion; Diseases; Potts model; Statistical Physics; Tissue regeneration, Cancer metastasis; Cell-cell contact; Cellular potts models; Chemical gradients; Cluster rearrangement; Intermediate cells; Lattice gas model; Migration velocity, Cells, article; case report; cell adhesion; cell migration; cell shape; clinical article; contact inhibition; human cell; physics; velocity
Department/Centre: Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 10 Aug 2021 11:40
Last Modified: 10 Aug 2021 11:40
URI: http://eprints.iisc.ac.in/id/eprint/69117

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