Mitochondria-targeted acridine-based dual-channel fluorescence chemosensor for detection of Sn4+ and Cr2O72- ions in water and its application in discriminative detection of cancer cells

Ravichandiran, P and Prabakaran, DS and Maroli, N and Kim, AR and Park, B-H and Han, M-K and Ramesh, T and Ponpandian, S and Yoo, DJ (2021) Mitochondria-targeted acridine-based dual-channel fluorescence chemosensor for detection of Sn4+ and Cr2O72- ions in water and its application in discriminative detection of cancer cells. In: Journal of Hazardous Materials, 419 .

	PDF J_Haz_Mat_419_2021.pdf - Published Version Restricted to Registered users only Download (10MB)
	Microsoft Word 1-s2.0-S030438942101373X-mmc1.docx - Published Supplemental Material Download (27MB)

Abstract

The goal of the present work was to fabricate a new low-cost, easy-to-prepare, dual-channel fluorescence chemosensor comprised of acridine-diphenylacetyl moieties (NDA) to enable remarkable Sn4+ detection in water and biological medium. The resulting NDA�Sn4+ complex was utilized for the distinguished identification of Cr2O72- ions from other anions and biomolecules. These investigations involve the absorption, fluorescence, and electrochemical methods for the detection of Sn4+ and Cr2O72- ions in pure water. The mechanism for NDA-mediated Sn4+ detection was experimentally determined by FT-IR, NMR titrations, mass (ESI) analyses, and DFT calculations. The obtained results indicate that the NDA chemosensor possessed excellent performance characteristics including good water solubility and compatibility, quick response time (less than 10 s), high sensitivity (Sn4+ = 0.268 μM and Cr2O72- = 0.160 μM), and selectivity against coexisting metals, anions, amino acids, and peptides. The chemosensor NDA induced negligible toxicity in live cells and was successfully utilized as a biomarker for the tracking of Sn4+ in human normal and cancer cells. More importantly, NDA demonstrates distinguished recognition of Sn4+ in human cancer cells rather than in normal live cells. Additionally, NDA was shown to act as a mitochondria-targeted probe in FaDu cells. © 2021 Elsevier B.V.

Item Type:	Journal Article
Publication:	Journal of Hazardous Materials
Publisher:	Elsevier B.V.
Additional Information:	The copyright for this article belongs to Elsevier B.V.
Department/Centre:	Division of Physical & Mathematical Sciences > Physics
Date Deposited:	06 Aug 2021 08:16
Last Modified:	06 Aug 2021 08:16
URI:	http://eprints.iisc.ac.in/id/eprint/68996

Actions (login required)

View Item