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Measuring and Modelling the Epithelial- Mesenchymal Hybrid State in Cancer: Clinical Implications

Jolly, MK and Murphy, RJ and Bhatia, S and Whitfield, HJ and Redfern, A and Davis, MJ and Thompson, EW (2022) Measuring and Modelling the Epithelial- Mesenchymal Hybrid State in Cancer: Clinical Implications. In: Cells Tissues Organs, 211 (2). 110 -133.

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Official URL: https://doi.org/10.1159/000515289


The epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We review here evidence for the presence, prognostic significance, and therapeutic potential of the E/M hybrid state in carcinoma. We further assess modelling predictions and validation studies to demonstrate stabilised E/M hybrid states along the spectrum of EMP, as well as computational approaches for characterising and quantifying EMP phenotypes, with particular attention to the emerging realm of single-cell approaches through RNA sequencing and protein-based techniques. © 2021

Item Type: Journal Article
Publication: Cells Tissues Organs
Publisher: S. Karger AG
Additional Information: The copyright for this article belongs to the Authors.
Keywords: Cancer; E/M hybrid · Partial epithelial- mesenchymal plasticity · Computational biology; epithelial transition; Epithelial-mesenchymal plasticity; Epithelial-mesenchymal transition; Mesenchymal; Molecular modelling
Department/Centre: Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited: 26 Jul 2021 09:35
Last Modified: 15 Jun 2022 05:07
URI: https://eprints.iisc.ac.in/id/eprint/68978

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