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Dauer formation in c. Elegans is modulated through awc and asi-dependent chemosensation

Pandey, P and Bhat, US and Singh, A and Joy, A and Birari, V and Kadam, NY and Babu, K (2021) Dauer formation in c. Elegans is modulated through awc and asi-dependent chemosensation. In: eNeuro, 8 (2).

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Official URL: https://doi.org/10.1523/ENEURO.0473-20.2021


The perception of our surrounding environment is an amalgamation of stimuli detected by sensory neurons. In Caenorhabditis elegans, olfaction is an essential behavior that determines various behavioral functions such as locomotion, feeding and development. Sensory olfactory cues also initiate downstream neuroendocrine signaling that controls aging, learning, development and reproduction. Innate sensory preferences toward odors (food, pathogens) and reproductive pheromones are modulated by 11 pairs of amphid chemosensory neurons in the head region of C. elegans. Amongst these sensory neurons, the ASI neuron has neuroendocrine functions and secretes neuropeptides, insulin-like peptide (DAF-28) and the TGF-b protein, DAF-7. Its expression levels are modulated by the presence of food (increased levels) and population density (decreased levels). A recent study has shown that EXP-1, an excitatory GABA receptor regulates DAF-7/TGF-b levels and partici-pates in DAF-7/TGF-b-mediated behaviors such as aggregation and bordering. Here, we show that exp-1 mutants show defective responses toward AWC-sensed attractive odors in a non-autonomous manner through ASI neurons. Our dauer experiments reveal that in daf-7 mutants, ASI expressed EXP-1 and STR-2 (a G-pro-tein-coupled receptor; GPCR) that partially maintained reproductive growth of animals. Further, studies sug-gest that neuronal connections between ASI and AWC neurons are allowed at least partially through ASI secreted DAF-7 or through alternate TGF-b pathway/s regulated by EXP-1 and STR-2. Together, our behav-ioral, genetic and imaging experiments propose that EXP-1 and STR-2 integrate food cues and allow the animals to display DAF-7/TGF-b neuroendocrine dependent or independent behavioral responses contributing to chemosensensory and developmental plasticity. © 2021 Pandey et al.

Item Type: Journal Article
Publication: eNeuro
Publisher: Society for Neuroscience
Additional Information: The copyright for this article belongs to Author
Department/Centre: Division of Biological Sciences > Centre for Neuroscience
Date Deposited: 12 Jul 2021 09:25
Last Modified: 12 Jul 2021 09:25
URI: http://eprints.iisc.ac.in/id/eprint/68824

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