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Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors

Liu, N and Gujrati, V and Malekzadeh-Najafabadi, J and Werner, JPF and Klemm, U and Tang, L and Chen, Z and Prakash, J and Huang, Y and Stiel, A and Mettenleiter, G and Aichler, M and Blutke, A and Walch, A and Kleigrewe, K and Razansky, D and Sattler, M and Ntziachristos, V (2021) Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors. In: Photoacoustics, 22 .

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Official URL: https://doi.org/10.1016/j.pacs.2021.100263


Contrast enhancement in optoacoustic (photoacoustic) imaging can be achieved with agents that exhibit high absorption cross-sections, high photostability, low quantum yield, low toxicity, and preferential bio-distribution and clearance profiles. Based on advantageous photophysical properties of croconaine dyes, we explored croconaine-based nanoparticles (CR780RGD-NPs) as highly efficient contrast agents for targeted optoacoustic imaging of challenging preclinical tumor targets. Initial characterization of the CR780 dye was followed by modifications using polyethylene glycol and the cancer-targeting c(RGDyC) peptide, resulting in self-assembled ultrasmall particles with long circulation time and active tumor targeting. Preferential bio-distribution was demonstrated in orthotopic mouse brain tumor models by multispectral optoacoustic tomography (MSOT) imaging and histological analysis. Our findings showcase particle accumulation in brain tumors with sustainable strong optoacoustic signals and minimal toxic side effects. This work points to CR780RGD-NPs as a promising optoacoustic contrast agent for potential use in the diagnosis and image-guided resection of brain tumors. © 2021 The Authors

Item Type: Journal Article
Publication: Photoacoustics
Publisher: Elsevier GmbH
Additional Information: The copyright for this article belongs to Authors
Keywords: Brain; Nanoparticles; Photoacoustic effect; Tumors, Absorption cross sections; Contrast Enhancement; Histological analysis; Optoacoustic imaging; Optoacoustic signals; Optoacoustic tomography; Particle accumulation; Photophysical properties, Diagnosis
Department/Centre: Division of Physical & Mathematical Sciences > Instrumentation Appiled Physics
Date Deposited: 15 Jul 2021 06:06
Last Modified: 15 Jul 2021 06:06
URI: http://eprints.iisc.ac.in/id/eprint/68781

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