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Mitochondrial genome stability in human: understanding the role of DNA repair pathways

Dahal, S and Raghavan, SC (2021) Mitochondrial genome stability in human: understanding the role of DNA repair pathways. In: Biochemical Journal, 478 (6). pp. 1179-1197.

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Official URL: https://doi.org/10.1042/BCJ20200920


Mitochondria are semiautonomous organelles in eukaryotic cells and possess their own genome that replicates independently. Mitochondria play a major role in oxidative phosphorylation due to which its genome is frequently exposed to oxidative stress. Factors including ionizing radiation, radiomimetic drugs and replication fork stalling can also result in different types of mutations in mitochondrial DNA (mtDNA) leading to genome fragility. Mitochondria from myopathies, dystonia, cancer patient samples show frequent mtDNA mutations such as point mutations, insertions and large-scale deletions that could account for mitochondria-associated disease pathogenesis. The mechanism by which such mutations arise following exposure to various DNA-damaging agents is not well understood. One of the well-studied repair pathways in mitochondria is base excision repair. Other repair pathways such as mismatch repair, homologous recombination and microhomology-mediated end joining have also been reported. Interestingly, nucleotide excision repair and classical nonhomologous DNA end joining are not detected in mitochondria. In this review, we summarize the potential causes of mitochondrial genome fragility, their implications as well as various DNA repair pathways that operate in mitochondria. © 2021 The Author(s).

Item Type: Journal Article
Publication: Biochemical Journal
Publisher: Portland Press Ltd
Additional Information: The copyright for this article belongs to Portland Press Ltd
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 20 Apr 2021 06:53
Last Modified: 20 Apr 2021 06:53
URI: http://eprints.iisc.ac.in/id/eprint/68639

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