Chitosan-glucuronic acid conjugate coated mesoporous silica nanoparticles: A smart pH-responsive and receptor-targeted system for colorectal cancer therapy

Narayan, R and Gadag, S and Cheruku, SP and Raichur, AM and Day, CM and Garg, S and Manandhar, S and Pai, KSR and Suresh, A and Mehta, CH and Nayak, Y and Kumar, N and Nayak, UY (2021) Chitosan-glucuronic acid conjugate coated mesoporous silica nanoparticles: A smart pH-responsive and receptor-targeted system for colorectal cancer therapy. In: Carbohydrate Polymers, 261 .

	PDF car_pol_261_2021.pdf - Published Version Restricted to Registered users only Download (14MB) | Request a copy
	Microsoft Word 1-s2.0-S0144861721002800-mmc1.docx - Published Supplemental Material Restricted to Registered users only Download (633kB) | Request a copy

Abstract

Glycosylated pH-sensitive mesoporous silica nanoparticles (MSNs) of capecitabine (CAP) were developed for targeting colorectal cancer. The MSNs possessed an average pore diameter of 8.12 ± 0.43 nm, pore volume of 0.73 ± 0.21 cm3/g, and particle size of 245.24 ± 5.75 nm. A high loading of 180.51 ± 5.23 mg/g attributed to the larger pore volume was observed. The surface of the drug-loaded MSNs were capped with chitosan-glucuronic acid (CHS-GCA) conjugate to combine two strategies viz. pH-sensitive, and lectin receptor mediated uptake. In vitro studies demonstrated a pH-sensitive and controlled release of CAP which was further enhanced in the presence of rat caecal content. Higher uptake of the (CAP-MSN)CHS-GCA was observed in HCT 116 cell lines. The glycosylated nanoparticles revealed reduction in the tumors, aberrant crypt foci, dysplasia and inflammation, and alleviation in the toxic features. This illustrated that the nanoparticles showed promising antitumor efficacy with reduced toxicity and may be used as a effective carrier against cancer. © 2021 Elsevier Ltd

Item Type:	Journal Article
Publication:	Carbohydrate Polymers
Publisher:	Elsevier Ltd
Additional Information:	The copyright for this article belongs to Elsevier Ltd
Keywords:	Cell culture; Chitosan; Controlled drug delivery; Glucose; Mesoporous materials; Particle size; pH sensors; Silica nanoparticles, Cancer therapy; Capecitabine; Colon cancer; Glucuronic acids; Glycosylated; Mesoporous silica nanoparticles; pH sensitive; PH-responsive; Pore diameters; Pore volume, Diseases
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	29 Mar 2021 07:00
Last Modified:	29 Mar 2021 07:00
URI:	http://eprints.iisc.ac.in/id/eprint/68578

Actions (login required)

View Item