Sarkar, R and Mukherjee, S (2021) Iridium-catalyzed enantioselective olefinic C(sp2)-H allylic alkylation. In: Chemical Science, 12 (8). pp. 3070-3075.
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Official URL: https://doi.org/10.1039/d0sc06208a
Abstract
The first iridium-catalyzed enantioselective olefinic C(sp2)-H allylic alkylation is developed in cooperation with Lewis base catalysis. This reaction, catalyzed by cinchonidine and anin situgenerated cyclometalated Ir(i)/phosphoramidite complex, makes use of the latent enolate character of an α,β-unsaturated carbonyl compound, namely coumalate ester, to introduce an allyl group at its α-position in a branched-selective manner in moderate to good yield with good to excellent enantioselectivities (up to 98 : 2 er).
| Item Type: | Journal Article |
|---|---|
| Publication: | Chemical Science |
| Publisher: | Royal Society of Chemistry |
| Additional Information: | The copyright for this article belongs to the Authors. |
| Keywords: | Alkylation; Allylation; Carbonyl compounds; Catalysis; Enantioselectivity, Allyl groups; Allylic alkylation; Enantioselective; Enolates; Lewis base; Unsaturated carbonyl compounds, Iridium compounds |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 24 Mar 2021 10:07 |
| Last Modified: | 22 May 2023 03:51 |
| URI: | https://eprints.iisc.ac.in/id/eprint/68520 |
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