Supramolecular synthons in 4-chloroanilinium-5-sulfosalicylate monohydrate: In vitro antioxidant and antimicrobial studies

Rajkumar, M and Parameswaran, K and Suresh, E and Chandramohan, A (2021) Supramolecular synthons in 4-chloroanilinium-5-sulfosalicylate monohydrate: In vitro antioxidant and antimicrobial studies. In: Journal of Molecular Structure, 1234 .

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Abstract

An organic molecular salt hydrate crystal, 4-chloroanilinium-5-sulfosalicylate monohydrate (4CA5SSA) was obtained in 2:2:1 ratio. A proton of SO3H group in 5-sulfosalicylic acid was transferred to nitrogen atom of 4-chloroaniline leading to form primary N�H�O hydrogen bonding in its crystal structure. R22(8) motif is also observed due to homo dimmer synthon of carboxylic acid. Further, the strong N�H�O and O�H�O hydrogen bonding interactions construct the supramolecular architecture whereas weak C�H�O hydrogen bonds play the dominant role in controlling the interactions between layers in 4CA5SSA salt hydrate. The thermal stability of title crystal was determined by TG/DTA thermogravimetric analysis. The in vitro antimicrobial activity of 4CA5SSA crystal was investigated against bacterial and fungal pathogens. The title compound was also evaluated for its in vitro antioxidant susceptibilities through DPPH radical scavenging methods. © 2021 Elsevier B.V.

Item Type:	Journal Article
Publication:	Journal of Molecular Structure
Publisher:	Elsevier B.V.
Additional Information:	The copyright for this article belongs to Elsevier B.V.
Keywords:	Antioxidants; Hydrates; Hydration; Hydrogen bonds; Supramolecular chemistry; Thermodynamic stability; Thermogravimetric analysis, 5-sulfosalicylic acid; Anti-microbial activity; Antimicrobial study; In-vitro; Molecular salts; Nitrogen atom; Organic salt hydrate; Organics; Salt hydrates; Supramolecular synthons, Microorganisms
Department/Centre:	Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	26 Mar 2021 06:27
Last Modified:	26 Mar 2021 06:27
URI:	http://eprints.iisc.ac.in/id/eprint/68498

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