ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

Regulation of miR-186-YY1 axis by the p53 translational isoform ∆40p53: implications in cell proliferation

Katoch, A and Tripathi, SK and Pal, A and Das, S (2021) Regulation of miR-186-YY1 axis by the p53 translational isoform ∆40p53: implications in cell proliferation. In: Cell Cycle, 20 (5-6). pp. 561-574.

Full text not available from this repository.
Official URL: https://doi.org/10.1080/15384101.2021.1875670


We have earlier shown that p53-FL and its translational isoform ∆40p53 are differentially regulated. In this study, we have investigated the cellular effect of ∆40p53 regulation on downstream gene expression, specifically miRNAs. Interestingly, ∆40p53 showed antagonistic regulation of miR-186-5p as compared to either p53 alone or a combination of both the isoforms. We have elucidated the miR-186-5p mediated effect of ∆40p53 in cell proliferation. Upon expression of ∆40p53, we observed a significant decrease in YY1 levels, an established target of miR-186-5p, which is involved in cell proliferation. Further assays with anti-miR-186 established the interdependence of ∆40p53− miR-186-5p−YY1− cell proliferation. The results unravel a new dimension toward the understanding of ∆40p53 functions, which seems to regulate cellular fate independent of p53FL.

Item Type: Journal Article
Publication: Cell Cycle
Publisher: Bellwether Publishing, Ltd.
Additional Information: The copyright of this article belongs to the Authors.
Keywords: cell proliferation; miR-186-5p; P53 isoform; YY1; ∆40p53
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 12 Mar 2021 15:57
Last Modified: 09 Jun 2023 09:10
URI: https://eprints.iisc.ac.in/id/eprint/68379

Actions (login required)

View Item View Item