Katoch, A and Tripathi, SK and Pal, A and Das, S (2021) Regulation of miR-186-YY1 axis by the p53 translational isoform �40p53: implications in cell proliferation. In: Cell Cycle .
Full text not available from this repository.Abstract
We have earlier shown that p53-FL and its translational isoform �40p53 are differentially regulated. In this study, we have investigated the cellular effect of �40p53 regulation on downstream gene expression, specifically miRNAs. Interestingly, �40p53 showed antagonistic regulation of miR-186-5p as compared to either p53 alone or a combination of both the isoforms. We have elucidated the miR-186-5p mediated effect of �40p53 in cell proliferation. Upon expression of �40p53, we observed a significant decrease in YY1 levels, an established target of miR-186-5p, which is involved in cell proliferation. Further assays with anti-miR-186 established the interdependence of �40p53� miR-186-5p�YY1� cell proliferation. The results unravel a new dimension toward the understanding of �40p53 functions, which seems to regulate cellular fate independent of p53FL. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
| Item Type: | Journal Article |
|---|---|
| Publication: | Cell Cycle |
| Publisher: | Bellwether Publishing, Ltd. |
| Additional Information: | The copyright of this article belongs to Bellwether Publishing, Ltd. |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology |
| Date Deposited: | 12 Mar 2021 15:57 |
| Last Modified: | 12 Mar 2021 15:58 |
| URI: | http://eprints.iisc.ac.in/id/eprint/68379 |
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