Mitochondrial dynamics, positioning and function mediated by cytoskeletal interactions

Shah, M and Chacko, LA and Joseph, JP and Ananthanarayanan, V (2021) Mitochondrial dynamics, positioning and function mediated by cytoskeletal interactions. In: Cellular and Molecular Life Sciences .

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Abstract

The ability of a mitochondrion to undergo fission and fusion, and to be transported and localized within a cell are central not just to proper functioning of mitochondria, but also to that of the cell. The cytoskeletal filaments, namely microtubules, F-actin and intermediate filaments, have emerged as prime movers in these dynamic mitochondrial shape and position transitions. In this review, we explore the complex relationship between the cytoskeleton and the mitochondrion, by delving into: (i) how the cytoskeleton helps shape mitochondria via fission and fusion events, (ii) how the cytoskeleton facilitates the translocation and anchoring of mitochondria with the activity of motor proteins, and (iii) how these changes in form and position of mitochondria translate into functioning of the cell. © 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature.

Item Type:	Journal Article
Publication:	Cellular and Molecular Life Sciences
Publisher:	Springer Science and Business Media Deutschland GmbH
Additional Information:	The copyright for this article belongs to Springer Science and Business Media Deutschland GmbH
Department/Centre:	Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering
Date Deposited:	13 Dec 2021 11:28
Last Modified:	13 Dec 2021 11:28
URI:	http://eprints.iisc.ac.in/id/eprint/68233

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