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Role of FoxO transcription factors in aging-associated cardiovascular diseases

Mishra, S and Ravi, V and Sundaresan, NR (2021) Role of FoxO transcription factors in aging-associated cardiovascular diseases. [Book Chapter]

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Official URL: https://doi.org/10.1016/bs.vh.2020.12.018


Aging constitutes a major risk factor toward the development of cardiovascular diseases (CVDs). The aging heart undergoes several changes at the molecular, cellular and physiological levels, which diminishes its contractile function and weakens stress tolerance. Further, old age increases the exposure to risk factors such as hypertension, diabetes and hypercholesterolemia. Notably, research in the past decades have identified FoxO subfamily of the forkhead transcription factors as key players in regulating diverse cellular processes linked to cardiac aging and diseases. In the present chapter, we discuss the important role of FoxO in the development of various aging-associated cardiovascular complications such as cardiac hypertrophy, cardiac fibrosis, heart failure, vascular dysfunction, atherosclerosis, hypertension and myocardial ischemia. Besides, we will also discuss the role of FoxO in cardiometabolic alterations, autophagy and proteasomal degradation, which are implicated in aging-associated cardiac dysfunction. © 2021 Elsevier Inc.

Item Type: Book Chapter
Publication: Vitamins and Hormones
Publisher: Academic Press Inc.
Additional Information: The copyright for this article belongs to Academic Press Inc.
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 29 Dec 2021 06:11
Last Modified: 29 Dec 2021 06:11
URI: http://eprints.iisc.ac.in/id/eprint/68213

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