Pandey, P and Singh, A and Kaur, H and Ghosh-Roy, A and Babu, K (2021) Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans. In: PLoS Genetics, 17 (2).
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Abstract
Ethanol is a widely used drug, excessive consumption of which could lead to medical conditions with diverse symptoms. Ethanol abuse causes dysfunction of memory, attention, speech and locomotion across species. Dopamine signaling plays an essential role in ethanol dependent behaviors in animals ranging from C. elegans to humans. We devised an ethanol dependent assay in which mutants in the dopamine autoreceptor, dop-2, displayed a unique sedative locomotory behavior causing the animals to move in circles while dragging the posterior half of their body. Here, we identify the posterior dopaminergic sensory neuron as being essential to modulate this behavior. We further demonstrate that in dop-2 mutants, ethanol exposure increases dopamine secretion and functions in a DVA interneuron dependent manner. DVA releases the neuropeptide NLP-12 that is known to function through cholinergic motor neurons and affect movement. Thus, DOP-2 modulates dopamine levels at the synapse and regulates alcohol induced movement through NLP-12. © 2021 Pandey et al.
| Item Type: | Journal Article |
|---|---|
| Publication: | PLoS Genetics |
| Publisher: | Public Library of Science |
| Additional Information: | Copyright: © 2021 Pandey et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Department/Centre: | Division of Biological Sciences > Centre for Neuroscience |
| Date Deposited: | 15 Mar 2021 11:12 |
| Last Modified: | 15 Mar 2021 11:12 |
| URI: | http://eprints.iisc.ac.in/id/eprint/68200 |
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